Istat troponin7/5/2023 Point-of-care i-STAT cardiac troponin I for assessment of patients with symptoms suggestive of acute coronary syndrome. Purposes: The purpose of this study is to compare fingerstick point-of-care (POC) testing for cardiac troponin I to conventional venipuncture POC testing using the i-STAT device. Further work is required to define species-specific reference intervals for cTnI. For I-Stat, the c Tn at 99th centile is 0.08 ng/L. In conclusion, the assessment of cTnI using the i-STAT®1 hand-held analyser shows promise as a humoral marker of cardiac pathology in mammalian species but not for avian and reptilian species. All avian and reptilian samples were below 0.00 µg/L even though overt cardiac pathology was noted in some of these animals. The majority of animals with concentrations of cTnI above 0.08 µg/L were subsequently shown to have pathology with potential cardiac involvement. Concentrations of cTnI below, equal to and well above a suggested cut-off of 0.08 µg/L were observed in mammalian species. All iStat-cTnI assays were performed at bedside by clinicians using the Abbott iStat cTnI, while the laboratory-cTnI samples were analysed at a Queensland. During routine health checks at the Zoological Society of London, 171 blood samples were collected from 36 different species (27 mammal, seven bird and two reptile) and were analysed for cTnI using the i-STAT®1 hand-held analyser. The secondary aim was to explore whether elevations in cTnI were related to underlying cardiac pathology. Future candidate tests include C-reactive protein, creatine kinase-MB, and tests useful for determining the speed of blood coagulation, such as the prothrombin time test (PT/INR). The primary aim of this feasibility study was to determine whether the i-STAT®1 hand-held analyser can be used to identify elevations of serum and plasma cTnI in a variety of non-domestic species. Due to the success of the i-STAT System with troponin testing, it was recommended that additional parameters should be leveraged within the ED department. Recent advances in human and domestic animal medicine have shown cardiac troponin I (cTnI) to be the biomarker of choice for myocardial damage. However due to the wide range of species dealt with and their different sizes, few techniques have been validated. Symptoms of a heart attack include indigestion and upper stomach pain in the middle arms and back. In the field of cardiology the diagnostic techniques used for domestic animals are also applied to exotic species. The high-sensitive troponin test is used to help doctors diagnose heart attacks and other potentially fatal heart conditions. One of the main challenges faced by veterinary surgeons in the field of zoo and wild animal medicine is the lack of published reference data and validated tests for non-domestic species. International Primate Heart Project, Cardiff Metropolitan University St Georges University Hospitals NHS Foundation Trust Zoological Society of London and International Primate Heart Project, Cardiff Metropolitan University While the i-STAT is very reliable and easy to use, i-STAT Troponin is less sensitive than the new Beckman hs-Troponin assay.
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